Source: BBC
Streets are empty and markets, banks and schools are closed to mark the abortive attempt in 1967 to gain independence for the region.
It led to a bitter three-year civil war in which more than one million people were killed.
The authorities have warned the secessionists against street protests and security forces are on patrol.
South-eastern Nigeria is mainly inhabited by the ethnic Igbo community, who often complain of marginalisation – accusing successive governments of failing to develop their areas.
In the last few years, there have been a resurgence of support for a breakaway state of Biafra led by the banned group Indigenous People of Biafra (Ipob) and the Movement for the Actualization of the Sovereign State of Biafra (Massob).
The BBC Igbo service says there has been a total shutdown in the Igbo heartland of Enugu and Anambra states.
The southern oil city of Port Harcourt as well as parts of Abia state have also been affected by the stay-away.
People have been sending in photos to BBC Igbo of deserted streets, including one of the iconic Niger River Bridge in Onitsha, known as the gateway to the east, which is usually congested with traffic.
Ipob leader Nnamdi Kanu is currently facing treason-related charges.
He has not been seen in public since last September when his house was raided by the Nigerian military. The army denies arresting him and his whereabouts are unknown.
Biafra at a glance:
- First republic of Biafra was declared by Nigerian military officer Odumegwu-Ojukwu in 1967
- He led his mainly ethnic Igbo forces into a deadly three-year civil war that ended in 1970
- More than one million people lost their lives, mostly because of hunger
- Decades after Biafra uprising was quelled by the military, secessionist groups have attracted the support of many young people
- They feel Nigeria’s central government is not investing in the region
- The government says their complaints are not particular to the south-east.