Manchester United has been knocked out of the Champions League following a 2-1 defeat to Sevilla in their last-16 second leg at Old Trafford on Tuesday.
Second-half substitute Wissam Ben Yedder scored twice in four minutes to send the Spanish underdogs into the quarter-finals of the competition for the first time.
Romelu Lukaku pulled one back for the Red Devils with six minutes remaining, but it was too little, too late for United to rally after 170 minutes of deadlock.
Despite a confidence-boosting victory over Liverpool on Saturday, the hosts reverted to the cautious approach, which restricted them to a goalless draw in Spain last month.
An earlier away goal would have forced United to change tact and Joaquin Correa came close when he glanced Ever Banega’s corner just over the crossbar at the near post.
Sevilla continued to create half-chances but the toothlessness of Luis Muriel, who also missed a golden opportunity in the first leg, hindered them more than once, and it was his replacement who was their hero.
Ben Yedder finally broke the stalemate on 74 minutes, only 88 seconds after being called upon off the bench, escaping the attention of Eric Bailly and rifling into the bottom corner from Pablo Sarabia’s pass.
That strike left United needing two because of their failure to score an away goal, and their task was made even more difficult four minutes later when Ben Yedder turned the ball home from Correa’s near-post flick-on.
David de Gea pushed the header onto the crossbar, but it dropped down and back over the line.
Jose Mourinho’s side briefly threatened another famous European comeback when Lukaku finished emphatically from close-range following a corner, but Chris Smalling and Anthony Martial missed late chances as United’s first Champions League knockout campaign in four years came to a disappointing end.